Application of data mining algorithms in research on traditional Chinese medicine formula / 中国药房

In recent years， data mining algorithms have been widely employed in scientific research within the field of traditional Chinese medicine （TCM）. The data mining algorithms are used to effectively handle and analyze the complex data in TCM formulas， providing a rational explanation for the mechanism of action. This method has proven particularly useful in uncovering patterns of compatibility and frequent combinations of herbs in TCM， thereby enhancing the reliability and accuracy of clinical diagnosis， target screening， and the study of new drugs. This paper reviews and analyzes 147 papers on TCM formula research that utilize data mining algorithms. The results indicate that data mining algorithms play a unique advantage in six sub- areas， including the study on the mechanism of action in TCM formula， the dose-efficacy of TCM formulas， the identification of core drugs pairs/groups， mining the relationships among “formulas-drug-symptom”， the discovery of new formulas， and mining the compatibility law. Notably， association rules and clustering algorithms are the most representative.

A bibliometric and visualization analysis of stem cell therapies for periodontal tissue engineering / 口腔疾病防治

Objective@# To analyze the current status, hotspots, and trends in the field of stem cell therapies for periodontal tissue engineering based on bibliometric analysis.@*Methods @# The literature on stem cell therapies for periodontal tissue engineering in animal experiments and clinical studies was searched in the Web of Science core database up to December 31, 2021. The bibliometric analysis of the relevant literature data was carried out by using the "Bibliometrix" package of R language.@*Results @#A total of 304 articles were included, and the number of publications and the citation frequency are increasing. The number of related studies from China ranks first in the world with 166 publications; the institution with the largest number of publications is the Fourth Military Medical University; the author with the largest number of publications is Jin Y; and Tissue Engineering Part A had the most related publications. The hotspots of stem cell therapies for periodontal tissue engineering are mainly focused on tissue engineering and periodontal ligament regeneration, while the frontiers are mainly focused on exosomes, gold nanoparticles, and angiogenesis. @*Conclusion@#Research on stem cell therapies for periodontal tissue engineering continues to expand, and the academic influence is gradually increasing. Future research directions should focus on periodontal ligament regeneration, exosomes, gold nanoparticles and angiogenesis.

Bibliometric and bioinformatics analysis of genetic literature on susceptibility to noise induced hearing loss / 中华劳动卫生职业病杂志

Objective: To summarize and analyse of literature on the susceptibility genes of noise induced hearing loss (NIHL) , and the key genes were screened and obtained by bioinformatics method, so as to provide reference for the prevention research of NIHL. Methods: In September 2021, Based on CNKI, NCBI Pubmed database and Web of Science database, this paper conducted bibliometric analysis and bioinformatics analysis on the genetic literature related to the susceptibility to noise-induced hearing loss from 1999 to 2020. Endnote X9 software and the WPS office software were used for bibliometric analysis, and online software STRING and Cytoscape software were used for bioinformatics analysis. Results: A total of 131 literatures were included in the study, involving 40 genes in total. Bibliometric analysis shows that 131 papers which included 36 Chinese articles and 95 English articles were published in 63 biomedical journals; the highest number of published articles was 19 in 2020. Bioinformatics analysis suggests that GAPDH、SOD2、SOD1、CAT、CASP3、IL6 and other genes play a key role in the interaction network. The involved pathways mainly include MAP2K and MAPK activations, PTEN regulation, P53-depardent G1 DNA damage response, signaoling by BRAF and RAF fusions and soon. Conclusion: The study of noise induced hearing loss involves multi gene biological information, and bioinformatics analysis is helpful to predict the occurrence and development of noise induced hearing loss.

Research status of occupational methanol poisoning based on literature bibliometrics / 中国职业医学

@#Objective To analyze the research status and hotspot of occupational methanol poisoning at home and abroad. Methods ， The China National Knowledge Resource Database Wanfang Data Knowledge Service Platform and Web of Science were used as the data sources. The relevant literatures on occupational methanol poisoning published in domestic and foreign ， Results journals up to June 30 2021 were searched. The bibliometrics was used to analyzed the literatures. A total of 255 literatures were included in analysis. There were 187 Chinese articles and 68 English articles. Most of Chinese articles were ， ， published from 2001 to 2005 with an average of 26.7 literatures per five years until June 2021. Among them 72 literatures （ ）， ， were published in core journals 38.5% and 176 authors from 27 provinces autonomous regions and municipality directly ， under the central government published relevant literatures. The research contents mainly focused on the classification ， ， poisoning mode clinical manifestations visual impairment and poisoning prevention and treatment of occupational methanol - ， poisoning. Most of the English literatures were published in 2016 2020 with an average of 4.9 articles per five years until June ， （ ）， 2021. Among them 36 were published in SCI journals 52.9% and 57 authors from 11 countries published relevant ， ， ， literatures. The research contents mainly focused on the clinical diagnosis drug treatment intoxication mechanism visual Conclusion sequelae and brain injury of occupational methanol poisoning. The research on occupational methanol poisoning ， ， ， mainly focuses on clinical diagnosis clinical manifestations treatment and prognosis and pathogenesis. The focus of relevant research at home and abroad is different.

Visualization analysis of traditional Chinese medicine for neurogenesis research based on CiteSpace / 中国中药杂志

To analyze the research hotspots and trends of traditional Chinese medicine(TCM) for neurogenesis with use of CiteSpace 5.7.R3 software. The bibliometrics analysis on the literatures of TCM for neurogenesis from 1987 to 2020 included in the CNKI database was conducted to visualize the number of papers, authors, institutions and keywords. Totally 736 literatures were included and the volume of annual publications showed an upward in volatility. At present, several stable research teams have been formed, which were represented by DING Fei, ZHOU Chong-jian and ZHOU Yong-hong, but the cooperation was not close among the teams. According to the analysis of research institutions, Institute of Diagnostics of Hunan University of Chinese Medicine and Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine produced largest number of literatures. The cooperation among institutions, with universities of TCM and affiliated hospitals as the main research force, was characterized by dominant cooperation among regional institutions and less cross-regional cooperation. Keywords analysis showed that in the field of TCM for neurogenesis, a lot of studies mainly focused on the disease field, treatment and medication, TCM therapy and molecular mechanism. The research on TCM therapy and molecular mechanism for neurogenesis of central nervous system will be the research hotspots in future.

Bibliometric analysis on the research of the social isolation of the elderly in recent 10 years based on Web of Science database / 中国实用护理杂志

Objective:To analyze the research hotspots, research directions and future trends of social isolation of the elderly in the past 10 years, so as to provide reference for future research.Methods:The literature on social isolation of the elderly included in the Web of Science database from 2010 to 2020 was retrieved, and bibliometrics analysis was conducted on the number of literature publications, key words, countries and institutions, keyword knowledge graph analysis and keyword emergence and other aspects using science citation analysis and Citespace5.7.R3 visualization software.Results:A total of 1 178 articles were included. The document volume showed a rising tendency, The majority of them was in Britain and the United States, less international cooperation among the author, issuing agency is given priority to with university. The research focuses on the mental health of the elderly, social isolation intervention methods, risk factors, quality of life and mortality, etc.Conclusions:The phenomenon of social isolation of the elderly has become a research hotspot in the international community, while China′s research in this field is still in its infancy. Future research should draw lessons from the experience and methods of foreign research, and explore intervention methods suitable for the social isolation of the elderly in China, so as to better promote the healthy aging of the elderly.

Literature research on application of Traditional Chinese Medicine nursing technology in the core nursing periodicals from 2013 to 2019 / 中国实用护理杂志

Objective@#By a statistical analysis and summary of the literature on Traditional Chinese Medicine (TCM) nursing technology published in the core nursing periodical, research the currect status of TCM nursing technology.@*Methods@#Retrieved CNKI database (CNKI) and Wanfang medical journal database,according to Chinese Journal Citation Report (2017 edition) of China Institute of science and Technology Information Research, Choose 10 core nursing periodicals and retrieve the experimental articles related to TCM nursing technology from January 1,2013 to January 1, 2019.this paper analyze time, resources, authors, fund-sponsored researches, statistical methods by bibliometrics analysis.@*Results@#A total of 624 papers were included,of which 132 were in 2013 and 124 in 2014, 103 in 2015, accounting for 57.5%. "Nursing Research" contains 227 articles, 100 "Chinese Journal of Modern Nursing, 98 "Journal of Nursing", accounting for 68.1%. The literature has been published in 28 provinces and cities, 117 in Jiangsu Province, 100 in Guangdong Province, and 89 in Shanghai, accounting for 62.6%. The source of funds for fund papers is mainly provinces and cities, accounting for 38.4%. Involving 22 TCM nursing technology operations, 762 applications, 174 acupoint massage, 113 auricular point application, 109 acupoint points, and 106 moxibustion methods, accounting for 66.3%. There are more than 120 types of diseases involved, mainly cancer, stroke, hypertension, and diabetes. There are more than 180 kinds of symptoms, mainly about pain, constipation, quality of life and so on.@*Conclusion@#TCM nursing research has made great progress, TCM nursing technology is currently widely used in clinical practice. Scientific research has also confirmed its effectiveness, but it lacks high-quality core papers. At the same time, due to the diversity of research content, there is a lack of evidence-based nursing research literature.

Hafnia alvei: uma revisão sistemática de literatura / Hafnia alvei: a review systems of literature

A presença de Enterobacteriaceae indica a qualidade higiênica dos produtos alimentícios. Dentro do grupo das bactérias que fazem parte dessa família está Hafnia alvei. Estudo bibliométrico é uma importante ferramenta metodológica de revisão sistemática para reunir e sintetizar as diversas informações que surgem sobre um tema, inclusive sobre os estudos relativos a micro- -organismos. O objetivo deste trabalho foi realizar um estudo bibliométrico sobre este agente. Para tal foi utilizada a base de dados Web of Science usando o nome do agente e o termo food para a busca e limitando a pesquisa entre 2007 e 2017. As informações principais dos documentos foram registradas, bem como a característica principal das publicações sobre o tema. Foram encontrados 42 artigos científicos que contemplaram os termos de busca. A maioria das publicações ocorreu em países e períodos onde ocorreram surtos alimentares e há uma grande pesquisa relacionada à genoma e resistência a antimicrobianos. Avalia-se que ainda existem várias oportunidades de pesquisa sobre os micro-organismos, visto que eles são pouco estudados, principalmente em nosso país.

The presence of Enterobacteriaceae indicates the hygienic quality of food products. As a part of this family, there is an emergent pathogen: Hafnia alvei. Bibliometrics appears as an important tool to gather and synthesize all the information that appears about the new microorganisms. The objective of this paper is to perform a systematic review of literature with bibliometric analysis in order to know the evolution of these bacteria and seek opportunities for new research. To do this, the Web of Science database was searched, individually searching for Hafnia alvei refining for "food". The articles found were analyzed from the annual production, countries, institutions, areas of knowledge, authors who produced the most and periodicals most used. A total of 42 articles were selected for Hafnia alvei. Most publications have occurred in countries and periods where there have been food outbreaks and there is great genomerelated research and antimicrobial resistance. It is evaluated that there are still several research opportunities on microorganisms, since they are little studied, mainly in our country.

Bibliometrics Analysis of the Scientific Publication of the Provincial Capital Cities CDC in China.

Aims: To objectively evaluate the level of scientific research of Centers for Disease Control and Prevention (CDCs) of the provincial capital cities in China. Design：To compare each capital city’s scientific research output in China, the authors used authoritative Chinese databases to retrieve scientific research literature published by the 31 Chinese provincial capital cities CDCs nationwide published between January 2007 and December 2011. Data were stored and analysed using NoteExpress2.0 software. Place and Duration of Study: Department of Medicineand the Centers for Disease Control and Prevention, between May 2012 and July 2012. Methodology: All the articles published by the CDCs of provincial capital cities between 2007 and 2011 were retrieved from scientific literature databases. Data were stored and analysed in NoteExpress2.0 reference management analysis software. Bibliometric methods were used to statistically analyze the data. We developed an Overall influence index (ΣIFN) which combined the number of published papers and the impact factor for each one (IF) to derive an overall and objective index. Results: Overall 9,445 Chinese language and 202 English language papers fulfilled our inclusion criteria. A gradual upward trend in published literature of provincial capital cities CDC was observed between 2007 and 2011. The co-author rate was relatively high and the content of the journals was extensive. The Overall influence index of Beijing CDC is the highest (626.682),and Lasa CDC gets the lowest(1.354). Conclusion: The development of the level of scientific research is uneven in different areas. The ΣIFN index of the developed regions is higher, and that of western under developed region is lower.